3,327 research outputs found
Panel discussion on chiral extrapolation of physical observables
This is an approximate reconstruction of the panel discussion on chiral
extrapolation of physical observables. The session consisted of brief
presentations from panelists, followed by responses from the panel, and
concluded with questions and comments from the floor with answers from
panelists. In the following, the panelists have summarized their statements,
and the ensuing discussion has been approximately reconstructed from notes.Comment: Lattice2002(plenary) 15 pages, 3 figure
Generalised Geometry for M-Theory
Generalised geometry studies structures on a d-dimensional manifold with a
metric and 2-form gauge field on which there is a natural action of the group
SO(d,d). This is generalised to d-dimensional manifolds with a metric and
3-form gauge field on which there is a natural action of the group .
This provides a framework for the discussion of M-theory solutions with flux. A
different generalisation is to d-dimensional manifolds with a metric, 2-form
gauge field and a set of p-forms for either odd or even on which there is a
natural action of the group . This is useful for type IIA or IIB
string solutions with flux. Further generalisations give extended tangent
bundles and extended spin bundles relevant for non-geometric backgrounds.
Special structures that arise for supersymmetric backgrounds are discussed.Comment: 31 page
Virus-induced translational arrest through 4EBP1/2-dependent decay of 5'-TOP mRNAs restricts viral infection
The mosquito-transmitted bunyavirus, Rift Valley fever virus (RVFV), is a highly successful pathogen for which there are no vaccines or therapeutics. Translational arrest is a common antiviral strategy used by hosts. In response, RVFV inhibits two well-known antiviral pathways that attenuate translation during infection, PKR and type I IFN signaling. Despite this, translational arrest occurs during RVFV infection by unknown mechanisms. Here, we find that RVFV infection triggers the decay of core translation machinery mRNAs that possess a 5'-terminal oligopyrimidine (5'-TOP) motif in their 5'-UTR, including mRNAs encoding ribosomal proteins, which leads to a decrease in overall ribosomal protein levels. We find that the RNA decapping enzyme NUDT16 selectively degrades 5'-TOP mRNAs during RVFV infection and this decay is triggered in response to mTOR attenuation via the translational repressor 4EBP1/2 axis. Translational arrest of 5'-TOPs via 4EBP1/2 restricts RVFV replication, and this increased RNA decay results in the loss of visible RNA granules, including P bodies and stress granules. Because RVFV cap-snatches in RNA granules, the increased level of 5'-TOP mRNAs in this compartment leads to snatching of these targets, which are translationally suppressed during infection. Therefore, translation of RVFV mRNAs is compromised by multiple mechanisms during infection. Together, these data present a previously unknown mechanism for translational shutdown in response to viral infection and identify mTOR attenuation as a potential therapeutic avenue against bunyaviral infection
Chiral Analysis of Quenched Baryon Masses
We extend to quenched QCD an earlier investigation of the chiral structure of
the masses of the nucleon and the delta in lattice simulations of full QCD.
Even after including the meson-loop self-energies which give rise to the
leading and next-to-leading non-analytic behaviour (and hence the most rapid
variation in the region of light quark mass), we find surprisingly little
curvature in the quenched case. Replacing these meson-loop self-energies by the
corresponding terms in full QCD yields a remarkable level of agreement with the
results of the full QCD simulations. This comparison leads to a very good
understanding of the origins of the mass splitting between these baryons.Comment: 23 pages, 6 figure
Conditional gene expression in the mouse using a Sleeping Beauty gene-trap transposon
BACKGROUND: Insertional mutagenesis techniques with transposable elements have been popular among geneticists studying model organisms from E. coli to Drosophila and, more recently, the mouse. One such element is the Sleeping Beauty (SB) transposon that has been shown in several studies to be an effective insertional mutagen in the mouse germline. SB transposon vector studies have employed different functional elements and reporter molecules to disrupt and report the expression of endogenous mouse genes. We sought to generate a transposon system that would be capable of reporting the expression pattern of a mouse gene while allowing for conditional expression of a gene of interest in a tissue- or temporal-specific pattern. RESULTS: Here we report the systematic development and testing of a transposon-based gene-trap system incorporating the doxycycline-repressible Tet-Off (tTA) system that is capable of activating the expression of genes under control of a Tet response element (TRE) promoter. We demonstrate that the gene trap system is fully functional in vitro by introducing the "gene-trap tTA" vector into human cells by transposition and identifying clones that activate expression of a TRE-luciferase transgene in a doxycycline-dependent manner. In transgenic mice, we mobilize gene-trap tTA vectors, discover parameters that can affect germline mobilization rates, and identify candidate gene insertions to demonstrate the in vivo functionality of the vector system. We further demonstrate that the gene-trap can act as a reporter of endogenous gene expression and it can be coupled with bioluminescent imaging to identify genes with tissue-specific expression patterns. CONCLUSION: Akin to the GAL4/UAS system used in the fly, we have made progress developing a tool for mutating and revealing the expression of mouse genes by generating the tTA transactivator in the presence of a secondary TRE-regulated reporter molecule. A vector like the gene-trap tTA could provide a means for both annotating mouse genes and creating a resource of mice that express a regulable transcription factor in temporally- and tissue-specific patterns for conditional gene expression studies. These mice would be a valuable resource to the mouse genetics community for purpose of dissecting mammalian gene function
Baryon Charge Radii and Quadrupole Moments in the 1/N_c Expansion: The 3-Flavor Case
We develop a straightforward method to compute charge radii and quadrupole
moments for baryons both with and without strangeness, when the number of QCD
color charges is N_c. The minimal assumption of the single-photon exchange
ansatz implies that only two operators are required to describe these baryon
observables. Our results are presented so that SU(3) flavor and isospin
symmetry breaking can be introduced according to any desired specification,
although we also present results obtained from two patterns suggested by the
quark model with gluon exchange interactions. The method also permits to
extract a number of model-independent relations; a sample is r^2_Lambda / r_n^2
= 3/(N_c+3), independent of SU(3) symmetry breaking.Comment: 30 pages, no figures, REVTeX
Coupling gauge theory to spinfoam 3d quantum gravity
We construct a spinfoam model for Yang-Mills theory coupled to quantum
gravity in three dimensional riemannian spacetime. We define the partition
function of the coupled system as a power series in g_0^2 G that can be
evaluated order by order using grasping rules and the recoupling theory. With
respect to previous attempts in the literature, this model assigns the
dynamical variables of gravity and Yang-Mills theory to the same simplices of
the spinfoam, and it thus provides transition amplitudes for the spin network
states of the canonical theory. For SU(2) Yang-Mills theory we show explicitly
that the partition function has a semiclassical limit given by the Regge
discretization of the classical Yang-Mills action.Comment: 18 page
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